Inherited abnormalities affecting the nervous system: genetic and psychiatric aspects

Diagnosis of inherited metabolic disorders affecting the nervous system.

Knowledge of the molecular causes for genetic diseases that affect the nervous system is rapidly expanding. Especially striking has been the finding in several autosomal dominant neurodegenerative disorders that unstable expansions of trinucleotide repeats are responsible for the genetic disorder and that the length of the repeat can be correlated with the age of onset and the severity of sympt...

Congenital abnormalities of the central nervous system.

Advances in genetics and molecular biology have led to a better understanding of the control of central nervous system (CNS) development. It is possible to classify CNS abnormalities according to the developmental stages at which they occur, as is shown below. The careful assessment of patients with these abnormalities is important in order to provide an accurate prognosis and genetic counselling.

Drugs Affecting the Central Nervous System

24. Introduction to Central Nervous System Pharmacology 281 Charles R. Craig 25.General Anesthesia: Intravenous and Inhalational Agents 291 David J. Smith and Michael B. Howie 26.Opioid and Nonopioid Analgesics 310 Sandra P. Welch and Billy R. Martin 27.Local Anesthetics 330 J. David Haddox 28.Agents Affecting Neuromuscular Transmission 338 Michael D. Miyamoto 29.Central Nervous System Stimulan...

Adhesion molecules and inherited diseases of the human nervous system.

Mutations in the human genes for the adhesion molecules Po, L1, and merosin cause severe abnormalities in nervous system development. Po and merosin are required for normal myelination in the nervous system, and L1 is essential for development of major axon pathways such as the corticospinal tract and corpus callosum. While mutations that lead to a loss of the adhesive function of these molecul...

Drugs Affecting the Autonomic Nervous System 83 General Organization and Functions of the Nervous System